CROSSTALK BETWEEN HUMAN BODY CONSTITUTIONAL TYPES IN MONGOLIAN TRADITIONAL MEDICINE AND IMMUNE RESPONSE TYPES
Abstract
Human constitutional typology system in Traditional Mongolian Medicine (TMM)explains not only the differences in physical characteristics, but somatic, mental, spiritual andbehavioral peculiarities of individuals and as well as environmental factors influencing on theirexistence. In TMM the typology system prescribes several human constitutional types in accordancewith domination of abstraction substances (or humors, or notions, or elements) Khii, Shar andBadgan and it may be specified into 3 single, 3 mixed or mixed and one collected human constitutionaltypes (Figure 1) and herewith each person have a own proportion of these substances determinedat the birth, tough the proportion may have to changed during the lifetime under influence of bothinternal and external factors, including aging, harmful and pathogenic factors. This review is aimedto analyze and summarize results of research works developed at the Mongolian National Universityof Medical Sciences (MNUMS) and which were focused on relationship between traditional andmodern medicines. There were 3 independent research and development projects was focused on relationshipbetween types of immune response and typology systems in TMM at the MNUMS during 2010–2019. In cytokine study project done in 93 blood donors were found low titer of pro-inflammatorycytokines, respectively low activation potential of T helper 1 (Th1) mediated inflammation has relatedwith Badgan humor domination, but relation of Shar humor with anti-inflammatory cytokines,therefore with Th2 mediated response was remained open. In chronic hepatitis B study were enrolled101 patients with certain phases of this pathology and established 1) immune active phase orcondition of CHB may be related with Khii humor; 2) reactivation phase / condition of CHB may berelated with Shar humor; and 3) inactive phase / condition — with Badgan humor. Study of peripheralblood white cells count in 287 blood donors demonstrated possible relationship between CD4+ T cellcount and Badgan humor, and iNKT cell count and Khii humor. Study of serum immunoglobulinand compliment titer was performed in 242 blood donors and demonstrated significantly higher C3titer in subjects with Badgan dominated humors. Also were shown direct intermediate correlationbetween titer of serum IgG and IgM and Shar humor expression score, and between titer of serumC3 and IgM Badgan humor expression score.On the basis of these findings were suggested: 1) Shar humor expression has an association withTh2 mediated adaptive immune response; 2) Badgan humor expression has an association with Th1mediated response; 3) and Khii humor has an intermediate position regulating Shar and Badganhumor expression and has an association with NKT cells, which likely to regulate Th1 and Th2mediated response activity. To ensure or decline above mentioned hypothesis there is required tocontinue and expand the research in this field.
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