FORMS OF THE DISEASE DYNAMICS OF CORONAVIRUS INFECTION, DEPENDING ON THE LIFESTYLE

Keywords: coronavirus, lifestyle, pandemic, COPD, alcohol

Abstract

The problem of the new coronavirus infection (COVID-19) has gained immense urgency due to its pandemic status. With this research, we tried to cover the issue in a way that would be interesting for both groups. We analyzed both the subjective health status of patients with coronavirus infection and the objective indicatorsof clinical and instrumental diagnostics. We examined such forms of unhealthy lifestyles as:smoking, alcohol abuse, recreational drug use and obesity in the focus of the course of COVID-19and related complications. For morphological accuracy, the sample of patients during the studywas stratified, including gradation, that is, the radical form of smoking is considered as COPD,and the critical form of alcoholism is represented by alcoholic hepatitis. This approach is neededto quantify lifestyle addiction over the dynamics of coronavirus infection. We also carried outanalytical work with the already available scientific publications of other authors, and, as a result,the statistical significance of the data obtained was calculated. Conclusion: lifestyle directly affectsthe severity of COVID-19, in many ways causing serious complications, often leading to death.The pathogenetic mechanisms of the outcome of the described bad habits are combined withthe pathogenesis of coronavirus infection, so the clinical picture becomes more terminal state. Wehave provided explanations for all the pro-inflammatory changes in the body. It can be argued thatadherence to a healthy lifestyle can minimize the risks of illness, and the presence of appropriatebad habits is a poor prognostic sign.

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Author Biographies

Savko Sergey Alekseevich, Pacific State Medical University

Student

Sturova Elena Valerievna, Pacific State Medical University (Vladivostok, Russia)

Associate professor, department of physical culture and sports

Stepanova Irina Sergeevna, Pacific State Medical University

Associate professor, department of physical culture and sports

References

Антонова Н.Н. Социально-экономическая обусловленность качества здоровья российского населения: социологический анализ // Вестник Волгогр. гос. ун-та. 2013. №1(19). С. 169–172

Газатова Н.Д., Юрова К.А., Гаврилов Д.В., Литвинова Л.С. Алкоголь и иммунитет // Гены и клетки. 2018. №13 (1). С. 47–55

Жигаев Д.С., Кику П.Ф., Шитер Н.С. Социальные факторы риска здоровью в структуре образа жизни // Здоровье. Медицинская экология. Наука. 2015. Т. 62, №4. С. 33–38

Казакова Е. В. Управление факторами риска, формирующими основу качества медицинской помощи и качества жизни в Дальневосточном федеральном округе // Тихоокеанский медицинский журнал. 2017. Т. 3. DOI: 10.17238/PmJ1609- 1175.2017.3.66-70

Какорина Е.П., Никитина С. Ю. Особенности структуры смертности в Российской Федерации // Проблемы социальной гигиены, здравоохранения и истории медицины. 2019. Вып. 27 (5) DOI: 10.32687/0869-866X-2019-27-5-822-826

Кику П.Ф., Ярыгина М. В., Юдин С.С. Образ жизни, среда обитания и здоровье населения Приморского края // Научное обозрение: реферативный журнал. 2015. №1. URL: http://abstractscience-review.ru/ru/article/view?id=159 (дата обращения: 25.12.2020)

Малыхина А. И., Гертанова Е. Ю., Каерова Е. В., Журавская Н. С., Дьяконова Т. М. Особенности образа жизни населения Владивостока // Проблемы социальной гигиены, здравоохранения и истории медицины. 2020. Т. 28(3). DOI: http://dx.doi.org/10.32687/0869-866X-2020-28-3-372-376

Московченко О. Н., Катцин О. А. Модель ориентирования студента ВУЗА на формирование здорового образа жизни // Вестник КемГУ. 2019. №3

Самохина И.В., Сагакянц А.Б. Работа в условиях пандемии COVID-19 — опыт биобанка ФГБУ «НМИЦ онкологии» Минздрава России // Кардиоваскулярная терапия и профилактика. 2020 Т. 19(6). DOI:10.15829/1728-8800-2020-2741

Сушенцева Н. Н., Попов О. С., Апалько С.В., Анисенкова А.Ю., Азаренко С.В., Сманцерев К.В., Хоботников Д.Н., Гладышева Т. В., Минина Е. В., Стрелюхина С. В., Уразов С. П., Павлович Д., Фридман С.Р., Щербак С. Г. Биобанк COVID-19: особенности цитокинового профиля // Кардиоваскулярная терапия и профилактика. 2020. Т. 19(6). DOI:10.15829/1728-8800-2020-2729

Хабриев Р. У., Щепин В. О., Миргородская О. В. Комплексная оценка целевых показателей здоровья населения Центрального федерального округа Российской Федерации // Проблемы социальной гигиены, здравоохранения и истории медицины. 2020. Т. 28 (3). DOI: http://dx.doi.org/10.32687/0869-866X-2020-28-3-349-354

Шестёра А. А., Кижунова В. Ю., Кику П. Ф., Кузьмина Т. Н., Стурова Е. В. Особенности состояния здоровья студентов высшего медицинского учебного заведения // Проблемы социальной гигиены, здравоохранения и истории медицины. 2020. Т. 28 (3). DOI: http://dx.doi.org/10.32687/0869866X-2020-28-3-400-404

Шестёра А. А., Хмельницкая Е. А., Кику П. Ф., Переломова О. В., Каерова Е. В., Сабирова К. М Физическое развитие и функциональные возможности молодежи города Владивостока // Здоровье населения и среда обитания. 2019.Т. 320 (11). URL: https://www.elibrary.ru/item.asp?id=42389828 (дата обращения: 25.12.2020)

Мулик А. Б., Улесикова И. В., Назаров Н. О., Срослова Г. А., Шатыр Ю. А. Влияние среды проживания на потребление алкоголя населением России // Проблемы социальной гигиены, здравоохранения и истории медицины. 2020. Т. 28 (4). DOI: http://dx.doi.org/10.32687/0869- 866X-2020-28-4-564-567

Alexander JK, Alpert MA. Hemodynamic alterations with obesity in man. In: Alpert MA Alexander JK eds. The heart and Lung in Obesity, Armonk, NY, Futura 1998. 45–46

Alpert MA, Alexander JK, Cardiac morphology and obesity in man. In: Alpert MA Alexander JK eds The heart and Lung in Obesity, Armonk, NY, Futura 1998. 25–44

Zhang L. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020

Cheng H., Wang Y. and Wang G. (2020) Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19. J. Med. Virol. 92, 726–730. 10.1002/jmv.25785

Crandall DL, Herzlinger HE, Saunders BD, Kral JG. Developmental aspects of the adipose tissue renin-angiotensin system: therapeutic implications. Drug Dev Res 1994; 32: 117–125

Cuadrado A, Nebreda AR. Mechanisms and functions of p38 MAPK signalling. Biochem J. 2010 Aug 1; 429(3):40-317

Engeli S., Negel R., Sharma A.M. Pathophysiology of the Adipose Tissue Renin-Angiotensin System Hypertension 2000; 35: 1270

Exley M.A., Hand L., O’Shea D., Lynch L. Interplay between the immune system and adipose tissue in obesity. J. Endocrinol. 2014;223:R41–R48. DOI:10.1530/JOE-13-0516

Farkash E.A., Wilson A.M., Jentzen J.M. Ultrastructural evidence for direct renal infection with SARS-CoV-2. J. Am. Soc. Nephrol. 2020 DOI:10.1681/ASN.2020040432

Gheblawi M., Wang K., Viveiros A., Nguyen Q., Zhong J.-C., Turner A.J. et al. . (2020) Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2. Circ. Res. 126, 1456–1474 10.1161/CIRCRESAHA.120.317015

Hoffmann M., Kleine-Weber H., Schroeder S., Krüger N., Herrler T., Erichsen S. et al. . (2020) SARSCoV2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor Cell 181, 271.e8–280.e8 10.1016/j.cell.2020.02.052

Lawrence T. (2009) The nuclear factor NF- k B pathway in inflammation. Cold Spring Harb. Perspect Biol. 110, 637–641

Li Q. and Verma I.M. (2002) NF-κB regulation in the immune system. Nat. Rev. Immunol. 2, 725–734

Lind P.A., Macgregor S., Heath A.C. et al. Association between in vivo alcohol metabolism and genetic variation in pathways that metabolize the carbon skeleton of ethanol and NADH reoxidation in the alcohol challenge twin study. Alcohol. Clin. Exp. Res. 2012; 36(12): 2074-85

Merad M., and Martin J.C.. 2020. Author Correction: Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages. Nat. Rev. Immunol. 20:448 10.1038/s41577020-0353-y Messerli FH, Christie B, DeCarvalho JGR et al Obesity and essential hypertension. Hemodynamics, intravascular volume, sodium excretion and plasma rennin activity, Arch Intern Med. - 1981.- 141. -81-85

Rajamaki K, Lappalainen J, Oorni K, Valimaki E, Matikainen S, Kovanen PT, Eklund KK. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS One. 2010;5:e11765

Strohle A., Wolters M., Hahn A. Alcohol intake--a two-edged sword. Part 1: metabolism and pathogenic effects of alcohol. Med. Monatsschr. Pharm. 2012; 35(8): 281-92

Zhou F., Yu T., Du R., Fan G., Liu Y., Liu Z., Xiang J., Wang Y., Song B., Gu X., et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 2020;395:1054–1062. DOI:10.1016/S0140-6736(20)30566-3

REFERENCES

Antonova N.N. Socio-economic conditionality of the quality of health of the Russian population: sociological analysis // Vestn. Volgogr. state un-that. Philos. 2013. No. 1 (19). Pp. 169–172

Gazatova N.D., Yurova K.A., Gavrilov D.V., Litvinova L.S. Alcohol and immunity // Genes and cells 2018.T. 13 (1). Pp. 47–55

Kakorina E. P., Nikitina S. Yu. Features of the structure of mortality in the Russian Federation Problemy socialnoi gigieni, zdravookhranenia i istorii meditsini. 2019. T. 27(5). DOI:10.32687/ 0869866X-2019-27-5-822-826 (in Russian)

Kazakova E. V. Management of risk factors that form the basis of quality of care and quality of life in the Far Eastern Federal District. Tihookeanskij meditsinskij zhurnal. 2017. №3. DOI:10.17238/PmJ16091175.2017.3.66-70 (in Russian)

Khabriev R. U., Schepin V. O., Mirgorodskaya O. V. The complex evaluation of target indices population health in the Central Federal Okrug of the Russian Federation. Problemi socialnoi gigieni, zdravookhranenia i istorii meditsini. 2020. T. 28(3)/ P. 349—354. DOI: http://dx.doi.org/10.32687/0869- 866X-2020-28-3-349-354 (in Russian)

Kiku P. F., Yarygina M. V., Yudin S. S. Lifestyle, environment and health of the population of Primorsky Krai. Nauchnoe obozrenie. 2015. №1. URL: http://abstract.science-review.ru/ru/article/ view?id=159 (in Russian)

Malykhina A.I., Gertanova E. Y., Kaerova E. V., Zhuravskaya N. S., Deaconova T. M. Lifestyle features of the population of the city of Vladivostok. Problemi socialnoi gigieni, zdravookhranenia i istorii meditsini. 2020. T. 28(3). Pp. 372—376. DOI: http://dx.doi.org/10.32687/0869-866X-2020-28-3-372-376 (in Russian)

Moskovchenko O. N., Kattsin O. A. Model of orientation of a university student on the formation of a healthy lifestyle. Vestnik KemGU. 2019. № 3 (in Russian)

Mulik A. B., Ulesikova I. V., Nazarov N. O., Sroslova G. A., Shatyr Yu. A. The impact of habitation environment on population alcohol consumption in Russia. Problemi socialnoi gigieni, zdravookhranenia i istorii meditsini. 2020. T. 28(4). P. 564— 567. DOI: http://dx.doi.org/10.32687/0869- 866X-2020-28-4-564-567 (in Russian)

Samokhina I.V., Sagakyants A.B. Work within the COVID-19 pandemic — the experience of the biobank of the National Medical Research Center of Oncology. Cardiovascular Therapy and Prevention. 2020 T. 19 (6). P. 2741. DOI: 10.15829/1728-8800-2020-2741 (in Russian)

Shestera A. A., Khmelnitskaya E. A., Kiku P. F., Perelomova O. V., Kayerova E. V., Sabirova K. M Physical development and functional capabilities of the youth of the city of Vladivostok. Zdorov’e naseleniya I sreda obitaniya. 2019. T. 320 (11). URL: https:// www.elibrary.ru/item.asp?id=42389828 (accessed 02.27.2020) (in Russian)

Shestera A. A., Kijunova V. Yu., Kiku P. F., Kuzmina T. N., Sturova E. V. The characteristics of health condition of students of medical university. Problemi socialnoi gigieni, zdravookhranenia i istorii meditsini. 2020. T. 28(3). P. 400—404. DOI: http://dx.doi.org/10.32687/0869-866X-2020-28-3-400-404 (in Russian)

Sushentseva N.N., Popov O.S., Apalko S.V., Anisenkova A. Yu., Azarenko S. V., Smantserev K. V., Khobotnikov D. N., Gladysheva T.V., Minina E.V., Strelyukhina S.V., Urazov S.P., Pavlovich D., Fridman S. R., Shcherbak S. G. COVID-19 biobank: features of the cytokine profile. Cardiovascular Therapy and Prevention. 2020. T. 19(6). DOI: 10.15829/1728-8800-2020-2729 (in Russian)

Zhigaev D.S., Kiku P.F., Shiter N.S. Social risk factors for health in the structure of lifestyle // Health Medical ecology. The science. 2015. T. 62(4). P. 33–38 (in Russian)

Alexander JK, Alpert MA. Hemodynamic alterations with obesity in man. In: Alpert MA Alexander JK eds. The heart and Lung in Obesity, Armonk, NY, Futura 1998. P. 45–46

Alpert MA, Alexander JK, Cardiac morphology and obesity in man. In: Alpert MA Alexander JK eds The heart and Lung in Obesity, Armonk, NY, Futura 1998. P. 25-44

Chen N., Zhou M., Dong X., Qu J., Gong F., Han Y., Qiu Y., Wang J., Liu Y., Wei Y., Xia J., Yu T., Zhang X., Zhang L. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020. T. 395. P. 507–513

Cheng H., Wang Y. and Wang G. (2020) Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19. J. Med. Virol. 92. P. 726–730

Crandall DL, Herzlinger HE, Saunders BD, Kral JG. Developmental aspects of the adipose tissue renin-angiotensin system: therapeutic implications. Drug Dev Res 1994. T. 32. Pp. 117–125

Cuadrado A, Nebreda AR. Mechanisms and functions of p38 MAPK signalling. Biochem J. 2010 Aug 1. T. 429(3):403-17

Engeli S., Negel R., Sharma A.M. Pathophysiology of the Adipose Tissue Renin-Angiotensin System Hypertension 2000. T. 35. 1270 p

Exley M.A., Hand L., O’Shea D., Lynch L. Interplay between the immune system and adipose tissue in obesity. J. Endocrinol. 2014;223:R41–R48. DOI:10.1530/JOE-13-0516

Farkash E.A., Wilson A.M., Jentzen J.M. Ultrastructural evidence for direct renal infection with SARS-CoV-2. J. Am. Soc. Nephrol. 2020. DOI:10.1681/ASN.2020040432

Gheblawi M., Wang K., Viveiros A., Nguyen Q., Zhong J.-C., Turner A.J. et al. (2020) Angiotensinconverting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2. Circ. Res. 126, 1456–1474 10.1161/CIRCRESAHA.120.317015

Hoffmann M., Kleine-Weber H., Schroeder S., Krüger N., Herrler T., Erichsen S. et al. . (2020) SARSCoV2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor Cell 181, 271.e8–280.e8 10.1016/j.cell.2020.02.052 Lawrence T. (2009) The nuclear factor NF- k B pathway in inflammation. Cold Spring Harb. Perspect Biol. 110. Pp. 637–641

Li Q. and Verma I.M. (2002) NF-κB regulation in the immune system. Nat. Rev. Immunol. 2 Pp. 725–734

Lind P.A., Macgregor S., Heath A.C. et al. Association between in vivo alcohol metabolism and genetic variation in pathways that metabolize the carbon skeleton of ethanol and NADH reoxidation in the alcohol challenge twin study. Alcohol. Clin. Exp. Res. 2012. T. 36(12). 2074-85

Merad M., and Martin J.C. 2020. Author Correction: Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages. Nat. Rev. Immunol. 20:448 10.1038/s41577020-0353-y

Messerli FH, Christie B, DeCarvalho JGR et al Obesity and essential hypertension. Hemodynamics, intravascular volume, sodium excretion and plasma rennin activity, Arch Intern Med. 1981. T. 141 Pp. 81–85

Rajamaki K, Lappalainen J, Oorni K, Valimaki E, Matikainen S, Kovanen PT, Eklund KK. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS One. 2010;5:e11765

Strohle A., Wolters M., Hahn A. Alcohol intake--a two-edged sword. Part 1: metabolism and pathogenic effects of alcohol. Med. Monatsschr. Pharm. 2012. T. 35(8). P. 281–92

Zhou F., Yu T., Du R., Fan G., Liu Y., Liu Z., Xiang J., Wang Y., Song B., Gu X., et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 2020. T. 395. P. 1054–1062. DOI:10.1016/S0140-6736(20)30566-3

Published
2021-04-02
How to Cite
Savko S. A., Sturova E. V., Stepanova I. S. FORMS OF THE DISEASE DYNAMICS OF CORONAVIRUS INFECTION, DEPENDING ON THE LIFESTYLE // Health, physical culture and sports, 2021. Vol. 21, № 1. P. 46-56. URL: https://hpcas.ru/article/view/9435.
Section
Medical and biological issues of human health
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