Clinical efficacy of phytopreparation Akhizunber in the treatment of oral candidiasis
Abstract
Abstract
Objectives: The incidence of oral mucosal diseases has increased in recent decades. due to the food, drugs, and toxic habits, as well as environmental pollution. The aim of this study was to evaluate clinical efficacy of phytopreparation Akhizunber in the treatment of oral candidiasis.
Materials and Methods: The study was performed at the Department of Operative Dentistry, School of Dentistry, Mongolian National University of Medical Sciences (MNUMS), Ulaanbaatar, Mongolia. After clinical assessment and diagnosis has been made, differentiation of Candida species and testing of their resistance to antifungal agents were performed. In experimental group administration of antifungal agents and local treatment with Akhizunber was done.
Results: Chronic atrophic candidiasis (42%) was the most frequent manifestation of oral candidiasis, followed by acute erythematous candidiasis (20%). A majority of patients diagnosed with acute forms of oral candidiasis (90%), chronic atrophic candidiasis (86%) and angular cheilitis (80%) were denture wearers. The prevalent fungal species isolated from the oral lesions was Candida albicans (86%). Antimycotic resistance tests revealed the the high activity of Fluconazole and Flucytosine against causative fungi. After local treatment of oral lesions with Akhizunber together with oral administration of antifungal agent full clinical cure was observed on 3rd-5th day of therapy in patients with acute candidiasis, and on 6-10th day in patients with chronic manifestations. Local treatment with Akhizunber accelerated the healing of mucosal lesions by 3-5 days in comparison with the use of povidone iodine.
Conclusion: Oral administration of antifungal agent in combination with the local treatment of oral lesions with Akhizunber in the therapy of patients with oral candidiasis showed high effectiveness and can be better alternative in comparison with other treatment choices.
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