QUALITY OF LIFE INDICATORS FOR ADOLESCENTS WITH CARRIAGE OF POLYMORPHIC VARIANTS OF FOLATE METABOLISM GENES
Abstract
Quality of life parameters provide the necessary information that goes beyond the scope of clinical symptoms and reflect the full picture of adolescent health status. Taking into account the characteristics of the quality of life of adolescents with the carriage of polymorphic variants of folate metabolism genes is important for the prevention of long-term negative consequences (depression, cognitive impairment, psycho-emotional lability). The study included 762 adolescents aged 15-16 years. Quality of life (QOL) indicators were assessed using the Russian version of the general PedsQL 4.0 questionnaire - range from 13 to 18 years (self-assessment). Determination of allelic variants of folate metabolism genes was carried out in the molecular genetics laboratory. It was determined that in girls the frequency of carriage of the A2756G polymorphism of the MTHFR gene in the homozygous state and the A66G polymorphism of the MTRR gene in the heterozygous state is significantly higher than in boys. Sexual characteristics of QOL parameters were found in carriers of the T677 and C677 alleles of the MTHFR gene. Smoothing of gender differences in QOL indices was revealed in adolescents with the presence of the 677 TT genotype of the MTHFR gene and the C 1298 allele of the MTHFR gene, which can be interpreted as a consequence of the negative effect on QOL. In order to prevent long-term negative consequences (depression, emotional lability, cognitive impairment, mental illness, thrombosis), it is necessary to study the quality of life parameters of adolescents with the determination of polymorphic replacements in folate genes for timely folate-vitamin correction and improvement of quality of life.
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